Sphingolipids (SP)

From LipidomicsWiki

Jump to: navigation, search

Contents

LIPID MAPS Subclasses


Basics

Sphingolipids (SP) are derivatives of long chain bases, as shown for ceramide and sphingosine-1-phosphate, and are composed of a hydrophobic moiety and a hydrophilic head group. They can be divided into two groups: the sphingophospholipids comprising of sphingomyelin, ceramide-1-phosphate, sphingosine-1-phosphate and sphingosylphosphorylcholine, and glycosphingolipids of the lacto-, globo- and ganglioside series.


Structures

Natural sources

Nomenclature

Biophysical properties

Biochemical pathways

Biochemical synthesis

Open Pathway in full window


Metabolism

Degradation

Biological processes associated

Link to Lipids as constituents of biological processes

Diseases

There are several disorders of sphingolipid metabolism, known as sphingolipidoses. The most common is Gaucher's disease. Also of note is Fabry's disease, an X-linked recessive condition wherein a buildup of glycosphingolipids in lysosomes of various tissues is due to alpha-galactosidase deficiency. These patients tend to present with peripheral neuropathies and develop chronic renal conditions.


Technology

Link to Lipidomics technologies

Analysis methods

Chemical synthesis

LipidomicNet Publications

Personal tools
Create a book