Sphingolipids (SP)
From LipidomicsWiki
Contents |
LIPID MAPS Subclasses
- Sphingoid bases (SP01)
- Ceramides (SP02)
- Phosphosphingolipids (SP03)
- Phosphonosphingolipids (SP04)
- Neutral glycosphingolipids (SP05)
- Acidic glycosphingolipids (SP06)
- Basic glycosphingolipids (SP07)
- Amphoteric glycosphingolipids (SP08)
- Arsenosphingolipids (SP09)
- Other Sphingolipids (SP00)
Basics
Sphingolipids (SP) are derivatives of long chain bases, as shown for ceramide and sphingosine-1-phosphate, and are composed of a hydrophobic moiety and a hydrophilic head group. They can be divided into two groups: the sphingophospholipids comprising of sphingomyelin, ceramide-1-phosphate, sphingosine-1-phosphate and sphingosylphosphorylcholine, and glycosphingolipids of the lacto-, globo- and ganglioside series.
Structures
Natural sources
Nomenclature
- IUPAC
- LIPID MAPS Classification Scheme
- Trivial - non systematic - names
Biophysical properties
Biochemical pathways
Biochemical synthesis
Metabolism
Degradation
Biological processes associated
Link to Lipids as constituents of biological processes
Diseases
There are several disorders of sphingolipid metabolism, known as sphingolipidoses. The most common is Gaucher's disease. Also of note is Fabry's disease, an X-linked recessive condition wherein a buildup of glycosphingolipids in lysosomes of various tissues is due to alpha-galactosidase deficiency. These patients tend to present with peripheral neuropathies and develop chronic renal conditions.
Technology
Link to Lipidomics technologies
Analysis methods
Chemical synthesis
LipidomicNet Publications
- Brodesser S, et al., (2011) | Dihydroceramide desaturase inhibition by a cyclopropanated dihydroceramide analog in cultured keratinocytes. J Lipids Article ID 724015