https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&feed=atom&action=history Glycerophosphoserines (GP03) - Revision history 2024-03-29T12:45:29Z Revision history for this page on the wiki MediaWiki 1.13.0 https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=5537&oldid=prev Katharina Rübsaamen: /* Structure */ 2008-08-13T11:19:33Z <p><span class="autocomment">Structure</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 11:19, 13 August 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Structure ===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Structure ===</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>&#160;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">[[Image:Phosphatidylserine.gif|frame|none|Phosphatidylserine]]</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Formula: C8H12NO10PR2</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Formula: C8H12NO10PR2</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Katharina Rübsaamen https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=5210&oldid=prev Katharina Rübsaamen: /* Nomenclature */ 2008-08-08T07:21:46Z <p><span class="autocomment">Nomenclature</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:21, 8 August 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 23:</td> <td colspan="2" class="diff-lineno">Line 23:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Nomenclature&nbsp; ===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Nomenclature&nbsp; ===</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==== Synonyms ====</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*Phosphatidylserine</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*Phosphatidyl-L-serine</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*1,2-Diacyl-sn-glycerol 3-phospho-L-serine</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*O3-Phosphatidyl-L-serine</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*3-O-sn-Phosphatidyl-L-serine</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://www.chem.qmul.ac.uk/iupac/lipid/ IUPAC]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://www.chem.qmul.ac.uk/iupac/lipid/ IUPAC]</div></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Katharina Rübsaamen https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=5209&oldid=prev Katharina Rübsaamen: /* Structure */ 2008-08-08T07:21:05Z <p><span class="autocomment">Structure</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:21, 8 August 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Structure ===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Structure ===</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">Formula: C8H12NO10PR2</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://www.lipidmaps.org/data/classification/gp.html LIPID MAPS Glycerophospholipid classes and subclasses]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://www.lipidmaps.org/data/classification/gp.html LIPID MAPS Glycerophospholipid classes and subclasses]</div></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Katharina Rübsaamen https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=5158&oldid=prev Gerhard Liebisch: Phosphatidylserine moved to Glycerophosphoserines (GP03) 2008-08-06T07:31:34Z <p><a href="/index.php/Phosphatidylserine" class="mw-redirect" title="Phosphatidylserine">Phosphatidylserine</a> moved to <a href="/index.php/Glycerophosphoserines_%28GP03%29" title="Glycerophosphoserines (GP03)">Glycerophosphoserines (GP03)</a></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:31, 6 August 2008</td> </tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Gerhard Liebisch https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=4958&oldid=prev Gerhard Liebisch: /* Technology */ 2008-07-28T15:43:57Z <p><span class="autocomment">Technology</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 15:43, 28 July 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 51:</td> <td colspan="2" class="diff-lineno">Line 51:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Technology ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Technology ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Analysis methods ===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Analysis methods ===</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* [[Phosphatidylserine - ESI-MS/MS - Liebisch et al.]]</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Chemical synthesis ===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Chemical synthesis ===</div></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Gerhard Liebisch https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=3293&oldid=prev Stefan Lehneis at 14:23, 20 March 2008 2008-03-20T14:23:51Z <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:23, 20 March 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 36:</td> <td colspan="2" class="diff-lineno">Line 36:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>===PS synthase===</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">=</ins>===PS synthase<ins class="diffchange diffchange-inline">=</ins>===</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>In the last years the endoplasmic reticulum and a novel ER-related fraction have been identified as the principal intracellular localization sites of PS-Synthase. The ER-related fraction is tightly associated with the mitochondria and currently referred to as the mitochondria-associated membrane (MAM) compartment. The MAM-compartment can be isolated as a distinct cellular fraction and has significant enrichment in PS-Synthase activity when compared with the total microsomal membrane population. Both morphological and biochemical studies have suggested that the zones of association between the MAM and the mitochondria may also be sites of contact between the outer and inner mitochondrial membrane (Fig. 26_2).</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>In the last years the endoplasmic reticulum and a novel ER-related fraction have been identified as the principal intracellular localization sites of PS-Synthase. The ER-related fraction is tightly associated with the mitochondria and currently referred to as the mitochondria-associated membrane (MAM) compartment. The MAM-compartment can be isolated as a distinct cellular fraction and has significant enrichment in PS-Synthase activity when compared with the total microsomal membrane population. Both morphological and biochemical studies have suggested that the zones of association between the MAM and the mitochondria may also be sites of contact between the outer and inner mitochondrial membrane (Fig. 26_2).</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Image:Figure26_2.jpg|frame|center|Figure 26_2. Synthesis and catabolism of phosphatidylserine to phosphatidyethanolamine]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Image:Figure26_2.jpg|frame|center|Figure 26_2. Synthesis and catabolism of phosphatidylserine to phosphatidyethanolamine]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>===PS Decarboxylase===</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">=</ins>===PS Decarboxylase<ins class="diffchange diffchange-inline">=</ins>===</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>PS-Decarboxylase was found to be a constituent of the inner mitochondrial membrane and there is a preference for the movement of newly synthesized PS to mitochondria. The PE generated in mitochondria does not only serve as a structural lipid in the mitochondria but is preferentially utilized as a substrate for the methyltransferase reaction to form PC and additionally is exported from mitochondria to function in the biogenesis of other organelles. The mechanism by which mitochondrial PE is transported to the plasma membrane is not known, but the process is energy dependent and insensitive to the Golgi disrupting toxin brefeldin A. The results with brefeldin A indicate that the route followed by PE is likely to bypass the Golgi apparatus.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>PS-Decarboxylase was found to be a constituent of the inner mitochondrial membrane and there is a preference for the movement of newly synthesized PS to mitochondria. The PE generated in mitochondria does not only serve as a structural lipid in the mitochondria but is preferentially utilized as a substrate for the methyltransferase reaction to form PC and additionally is exported from mitochondria to function in the biogenesis of other organelles. The mechanism by which mitochondrial PE is transported to the plasma membrane is not known, but the process is energy dependent and insensitive to the Golgi disrupting toxin brefeldin A. The results with brefeldin A indicate that the route followed by PE is likely to bypass the Golgi apparatus.</div></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Stefan Lehneis https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=3292&oldid=prev Stefan Lehneis at 14:23, 20 March 2008 2008-03-20T14:23:10Z <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 14:23, 20 March 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 26:</td> <td colspan="2" class="diff-lineno">Line 26:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://www.lipidmaps.org/data/classification/gp.html Glycerophospholipids and subclasses]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://www.lipidmaps.org/data/classification/gp.html Glycerophospholipids and subclasses]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>==<del class="diffchange diffchange-inline">Synthesis</del>==</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>==<ins class="diffchange diffchange-inline">= Biophysical properties =</ins>==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Biology / biochemistry ==</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">=== Biochemical synthesis===</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>PS is formed by the condensation of serine with a [[Phosphatidic acid|phosphatidic acid]] (PA) moiety, where in mammalian cells [[phosphatidylcholine]] or [[phosphatidylethanolamine]] serve as the phosphatidyl donors catalyzed by PS-Synthases (PSS I/II) (Fig. 25_2). Nascent PS is subsequently decarboxylated to form PE, and this reaction is catalyzed by PS-Decarboxylase (PSD).</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>PS is formed by the condensation of serine with a [[Phosphatidic acid|phosphatidic acid]] (PA) moiety, where in mammalian cells [[phosphatidylcholine]] or [[phosphatidylethanolamine]] serve as the phosphatidyl donors catalyzed by PS-Synthases (PSS I/II) (Fig. 25_2). Nascent PS is subsequently decarboxylated to form PE, and this reaction is catalyzed by PS-Decarboxylase (PSD).</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This pathway is found in mammalian cells but there are some tight restrictions on specific elements of the pathway. The methylation of PE only occurs quantitatively significant in the liver.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This pathway is found in mammalian cells but there are some tight restrictions on specific elements of the pathway. The methylation of PE only occurs quantitatively significant in the liver.</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 42:</td> <td colspan="2" class="diff-lineno">Line 44:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>PS-Decarboxylase was found to be a constituent of the inner mitochondrial membrane and there is a preference for the movement of newly synthesized PS to mitochondria. The PE generated in mitochondria does not only serve as a structural lipid in the mitochondria but is preferentially utilized as a substrate for the methyltransferase reaction to form PC and additionally is exported from mitochondria to function in the biogenesis of other organelles. The mechanism by which mitochondrial PE is transported to the plasma membrane is not known, but the process is energy dependent and insensitive to the Golgi disrupting toxin brefeldin A. The results with brefeldin A indicate that the route followed by PE is likely to bypass the Golgi apparatus.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>PS-Decarboxylase was found to be a constituent of the inner mitochondrial membrane and there is a preference for the movement of newly synthesized PS to mitochondria. The PE generated in mitochondria does not only serve as a structural lipid in the mitochondria but is preferentially utilized as a substrate for the methyltransferase reaction to form PC and additionally is exported from mitochondria to function in the biogenesis of other organelles. The mechanism by which mitochondrial PE is transported to the plasma membrane is not known, but the process is energy dependent and insensitive to the Golgi disrupting toxin brefeldin A. The results with brefeldin A indicate that the route followed by PE is likely to bypass the Golgi apparatus.</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">=== Metabolism ===</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">=== Enzymes/gene lists ===</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">=== Associated biological processes ===</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Technology ==</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">=== Analysis methods ===</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">=== Chemical synthesis ===</ins></div></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Stefan Lehneis https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=2510&oldid=prev Stefan Lehneis at 08:48, 17 April 2007 2007-04-17T08:48:14Z <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:48, 17 April 2007</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 10:</td> <td colspan="2" class="diff-lineno">Line 10:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://www.lipidmaps.org/data/classification/gp.html LIPID MAPS Glycerophospholipid classes and subclasses]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://www.lipidmaps.org/data/classification/gp.html LIPID MAPS Glycerophospholipid classes and subclasses]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Phosphatidylserine is made up of a glycerophosphate skeleton linked to two fatty acid molecules and the amino acid L-serine. It is an amphiphilic molecule because it is made up of the lipophilic fatty acid tails on one side and the hydrophilic head group containing phosphate and serine on the other side of the molecule.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">[[</ins>Phosphatidylserine<ins class="diffchange diffchange-inline">]] </ins>is made up of a glycerophosphate skeleton linked to two fatty acid molecules and the amino acid L-serine. It is an amphiphilic molecule because it is made up of the lipophilic fatty acid tails on one side and the hydrophilic head group containing phosphate and serine on the other side of the molecule.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>===Location===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>===Location===</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Phosphatidylserine is located in the internal layers of biologic membranes, facing the cytoplasm with its polar head group. In animal tissues, phosphatidylserine is formed from [[phosphatidylethanolamine]] by exchange of the ethanolamine head for L-serine. &nbsp;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">[[</ins>Phosphatidylserine<ins class="diffchange diffchange-inline">]] </ins>is located in the internal layers of biologic membranes, facing the cytoplasm with its polar head group. In animal tissues, <ins class="diffchange diffchange-inline">[[Phosphatidylserine|</ins>phosphatidylserine<ins class="diffchange diffchange-inline">]] </ins>is formed from [[phosphatidylethanolamine]] by exchange of the ethanolamine head for L-serine. &nbsp;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Natural sources ===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== Natural sources ===</div></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Stefan Lehneis https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=2509&oldid=prev Stefan Lehneis at 08:47, 17 April 2007 2007-04-17T08:47:29Z <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:47, 17 April 2007</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Basics==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Basics==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&nbsp; &nbsp;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&nbsp; &nbsp;</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Phosphatidylserine is known chemically as 1,2-diacyl-sn-glycerol-(3)-L-phosphoserine. It is abbreviated as Ptd Ser, Acyl2 Gro PSer and PS.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">[[</ins>Phosphatidylserine<ins class="diffchange diffchange-inline">]] </ins>is known chemically as 1,2-diacyl-sn-glycerol-(3)-L-phosphoserine. It is abbreviated as Ptd Ser, Acyl2 Gro PSer and PS.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Phosphatidylserine was first isolated from brain lipids called cephalins.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Phosphatidylserine was first isolated from brain lipids called cephalins.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Stefan Lehneis https://www.lipidomicnet.org/index.php?title=Glycerophosphoserines_%28GP03%29&diff=2508&oldid=prev Stefan Lehneis: /* Synthesis */ 2007-04-17T08:45:18Z <p><span class="autocomment">Synthesis</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 08:45, 17 April 2007</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 28:</td> <td colspan="2" class="diff-lineno">Line 28:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Synthesis==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Synthesis==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>PS is formed by the condensation of serine with a phosphatidic acid (PA) moiety, where in mammalian cells [[phosphatidylcholine]] or [[phosphatidylethanolamine]] serve as the phosphatidyl donors catalyzed by PS-Synthases (PSS I/II) (Fig. 25_2). Nascent PS is subsequently decarboxylated to form PE, and this reaction is catalyzed by PS-Decarboxylase (PSD).</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>PS is formed by the condensation of serine with a <ins class="diffchange diffchange-inline">[[Phosphatidic acid|</ins>phosphatidic acid<ins class="diffchange diffchange-inline">]] </ins>(PA) moiety, where in mammalian cells [[phosphatidylcholine]] or [[phosphatidylethanolamine]] serve as the phosphatidyl donors catalyzed by PS-Synthases (PSS I/II) (Fig. 25_2). Nascent PS is subsequently decarboxylated to form PE, and this reaction is catalyzed by PS-Decarboxylase (PSD).</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This pathway is found in mammalian cells but there are some tight restrictions on specific elements of the pathway. The methylation of PE only occurs quantitatively significant in the liver.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>This pathway is found in mammalian cells but there are some tight restrictions on specific elements of the pathway. The methylation of PE only occurs quantitatively significant in the liver.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <!-- diff generator: internal 2024-03-29 12:45:29 --> </table> Stefan Lehneis