Glycerophosphoethanolamines (GP02)
From LipidomicsWiki
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- | + | == Basics == | |
+ | === Structure === | ||
- | + | [[Image:PE_1.gif|frame|none|Phosphatidylethanolamine]] | |
- | Phosphatidylethanolamine | + | |
- | + | ||
+ | Formula: C7H12NO8PR2 | ||
- | == | + | === Natural sources === |
- | Phosphatidylethanolamine itself is synthesized from diacylglycerol and CDP-ethanolamine via the “Kennedy pathway” employing similar biochemical reaction steps as for [[phosphatidylcholine]]. Thus, the formed PE can be sequentially methylated on its primary amine using S-adenosylmethionine as the methyl donor by the enzyme PE-N-Methyl-Transferase (PEMT) to form PC after the sequential transfer of 3 methyl groups. These sequential reactions are termed the PEMT pathway. | + | === Nomenclature === |
+ | |||
+ | ==== Synonyms ==== | ||
+ | *Phosphatidylethanolamine | ||
+ | *(3-Phosphatidyl)ethanolamine | ||
+ | *(3-Phosphatidyl)-ethanolamine | ||
+ | *Cephalin | ||
+ | *1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine | ||
+ | *O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine | ||
+ | |||
+ | === Biophysical properties === | ||
+ | [[Phosphatidylethanolamine|Phosphatidylethanolamine (PE)]] was once given the trivial name 'cephalin'. | ||
+ | [[Phosphatidylethanolamine|PE]] is usually the second most abundant phospholipid in animal and plant lipids and it is frequently the main lipid component of microbial membranes and obviously a key building block of membrane bilayers. It is a neutral or zwitterionic phospholipid (at least in the pH range 2 to 7). | ||
+ | |||
+ | == Biology / biochemistry == | ||
+ | === Biochemical synthesis=== | ||
+ | [[Phosphatidylethanolamine|Phosphatidylethanolamine]] itself is synthesized from diacylglycerol and CDP-ethanolamine via the “Kennedy pathway” employing similar biochemical reaction steps as for [[phosphatidylcholine]]. Thus, the formed [[Phosphatidylethanolamine|PE]] can be sequentially methylated on its primary amine using S-adenosylmethionine as the methyl donor by the enzyme PE-N-Methyl-Transferase (PEMT) to form PC after the sequential transfer of 3 methyl groups. These sequential reactions are termed the PEMT pathway. | ||
+ | |||
+ | |||
+ | === Metabolism === | ||
+ | === Enzymes/gene lists === | ||
+ | === Associated biological processes === | ||
+ | |||
+ | == Technology == | ||
+ | === Analysis methods === | ||
+ | * [[Phosphatidylethanolamine - ESI-MS/MS - Liebisch et al.]] | ||
+ | * [[Phosphatidylethanolamine-based plasmalogens - ESI-MS/MS - Liebisch et al.]] | ||
+ | === Chemical synthesis === | ||
+ | |||
+ | [[Category:Glycerophospholipids (GP)]] |
Current revision
Contents |
Basics
Structure
Formula: C7H12NO8PR2
Natural sources
Nomenclature
Synonyms
- Phosphatidylethanolamine
- (3-Phosphatidyl)ethanolamine
- (3-Phosphatidyl)-ethanolamine
- Cephalin
- 1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine
- O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine
Biophysical properties
Phosphatidylethanolamine (PE) was once given the trivial name 'cephalin'. PE is usually the second most abundant phospholipid in animal and plant lipids and it is frequently the main lipid component of microbial membranes and obviously a key building block of membrane bilayers. It is a neutral or zwitterionic phospholipid (at least in the pH range 2 to 7).
Biology / biochemistry
Biochemical synthesis
Phosphatidylethanolamine itself is synthesized from diacylglycerol and CDP-ethanolamine via the “Kennedy pathway” employing similar biochemical reaction steps as for phosphatidylcholine. Thus, the formed PE can be sequentially methylated on its primary amine using S-adenosylmethionine as the methyl donor by the enzyme PE-N-Methyl-Transferase (PEMT) to form PC after the sequential transfer of 3 methyl groups. These sequential reactions are termed the PEMT pathway.
Metabolism
Enzymes/gene lists
Associated biological processes
Technology
Analysis methods
- Phosphatidylethanolamine - ESI-MS/MS - Liebisch et al.
- Phosphatidylethanolamine-based plasmalogens - ESI-MS/MS - Liebisch et al.