Glycerophosphoethanolamines (GP02)
From LipidomicsWiki
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- | + | == Basics == | |
- | + | === Structure === | |
- | == | + | === Natural sources === |
+ | === Nomenclature === | ||
+ | === Biophysical properties === | ||
[[Phosphatidylethanolamine|Phosphatidylethanolamine (PE)]] was once given the trivial name 'cephalin'. | [[Phosphatidylethanolamine|Phosphatidylethanolamine (PE)]] was once given the trivial name 'cephalin'. | ||
[[Phosphatidylethanolamine|PE]] is usually the second most abundant phospholipid in animal and plant lipids and it is frequently the main lipid component of microbial membranes and obviously a key building block of membrane bilayers. It is a neutral or zwitterionic phospholipid (at least in the pH range 2 to 7). | [[Phosphatidylethanolamine|PE]] is usually the second most abundant phospholipid in animal and plant lipids and it is frequently the main lipid component of microbial membranes and obviously a key building block of membrane bilayers. It is a neutral or zwitterionic phospholipid (at least in the pH range 2 to 7). | ||
- | + | == Biology / biochemistry == | |
- | == | + | === Biochemical synthesis=== |
[[Phosphatidylethanolamine|Phosphatidylethanolamine]] itself is synthesized from diacylglycerol and CDP-ethanolamine via the “Kennedy pathway” employing similar biochemical reaction steps as for [[phosphatidylcholine]]. Thus, the formed [[Phosphatidylethanolamine|PE]] can be sequentially methylated on its primary amine using S-adenosylmethionine as the methyl donor by the enzyme PE-N-Methyl-Transferase (PEMT) to form PC after the sequential transfer of 3 methyl groups. These sequential reactions are termed the PEMT pathway. | [[Phosphatidylethanolamine|Phosphatidylethanolamine]] itself is synthesized from diacylglycerol and CDP-ethanolamine via the “Kennedy pathway” employing similar biochemical reaction steps as for [[phosphatidylcholine]]. Thus, the formed [[Phosphatidylethanolamine|PE]] can be sequentially methylated on its primary amine using S-adenosylmethionine as the methyl donor by the enzyme PE-N-Methyl-Transferase (PEMT) to form PC after the sequential transfer of 3 methyl groups. These sequential reactions are termed the PEMT pathway. | ||
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+ | === Metabolism === | ||
+ | === Enzymes/gene lists === | ||
+ | === Associated biological processes === | ||
+ | |||
+ | == Technology == | ||
+ | === Analysis methods === | ||
+ | === Chemical synthesis === | ||
+ | |||
+ | [[Category:Glycerophospholipids (GP)]] |
Revision as of 15:20, 20 March 2008
Contents |
Basics
Structure
Natural sources
Nomenclature
Biophysical properties
Phosphatidylethanolamine (PE) was once given the trivial name 'cephalin'. PE is usually the second most abundant phospholipid in animal and plant lipids and it is frequently the main lipid component of microbial membranes and obviously a key building block of membrane bilayers. It is a neutral or zwitterionic phospholipid (at least in the pH range 2 to 7).
Biology / biochemistry
Biochemical synthesis
Phosphatidylethanolamine itself is synthesized from diacylglycerol and CDP-ethanolamine via the “Kennedy pathway” employing similar biochemical reaction steps as for phosphatidylcholine. Thus, the formed PE can be sequentially methylated on its primary amine using S-adenosylmethionine as the methyl donor by the enzyme PE-N-Methyl-Transferase (PEMT) to form PC after the sequential transfer of 3 methyl groups. These sequential reactions are termed the PEMT pathway.