EU Framework VII project "LipidomicNet"

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== Project description  ==
== Project description  ==
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*Project acronym: LipidomicNet  
*Project acronym: LipidomicNet  
*Grant agreement no.: 202272  
*Grant agreement no.: 202272  
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*Project duration: 2007 - 2012
*[[Beneficiary|Project partners]]
*[[Beneficiary|Project partners]]

Current revision

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Project description

  • LipidomicNet is a LARGE-SCALE INTEGRATING PROJECT within the SEVENTH FRAMEWORK PROGRAM of the European Commission
  • Project full title: LIPID DROPLETS AS DYNAMIC ORGANELLES OF FAT DEPOSITION AND RELEASE: TRANSLATIONAL RESEARCH TOWARDS HUMAN DISEASE
  • Project acronym: LipidomicNet
  • Grant agreement no.: 202272
  • Project duration: 2007 - 2012
  • Project partners


Project summary

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quantification of alterations of the total lipid profile after specific perturbations. In combination with advanced proteome and transcriptome analysis tools and novel imaging techniques using RNA interference, it is now possible to unravel the complex network between lipids, genes and proteins in an integrated lipidomics approach. This project application of the European Lipidomics Initiative (ELife) addresses lipid droplets (LD) as dynamic organelles with regard to composition, metabolism and regulation. LD are the hallmark of energy overload diseases with a major health care impact in Europe. The project exploits recent advances in lipidomics to establish highthroughput methods to define drugable targets and novel biomarkers related to LD lipid and protein species, their interaction and regulation during assembly, disassembly and storage. Translational research from mouse to man applied to LD pathology is a cornerstone of this project at the interface between research and development. To maximize the value of the assembled data generated throughout the project, “LipidomicNet” as a detailed special purpose Wiki formate data base is being developed and linked into the existing Lipidomics Expertise Platform (LEP) established through the SSA ELife project. ELife collaborates with the NIH initiative LIPID MAPS and the Japanese pendant Lipid Bank - Japan and is connected to the Danubian Biobank consortium Danubian Biobank consortium for clinical lipidomics.

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