Steering Committee Meeting - 07/2009

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  Monday, 13.07.2009

Time Monday, 13.07.2009
08:30 - 08:40 Introduction / Welcome

(Prof. G. Schmitz, Regensburg)

Presentations of the LipidomicNet Scientific Advisory Committee
08:40 - 09:05 Prof. M. Wenk Lipidomics, novel tools and applications
09:05 - 09:35 Prof. E. Dennis LIPID MAPS Lipidomics Initiative and Eicosanomics
09:35 - 09:55 Prof. D. Brasaemle The role of perilipin in control of lipolysis
Work package and deliverable-orientated presentations

WP 1

(Chair: Prof. G. Schmitz P01)

Scientific management
09:55-10:05 J. Jonas (P01) Scientific Management Report
10:05-10:30 Coffee Break

WP 2, together with TF I - IV

(Chair: Prof. C. Thiele)

Enabling technologies
10:30-10:40 WP2.1: Dr. G. Liebisch (P01) Analysis of glycerophosphoplipid species
10:40-10:50 WP2.1: M. Scherer (P01) Analysis of sphingolipid species
10:50-11:00 WP 2.3: Dr. J. Hansen/Protagen (P20) Identification of novel lipidomic targets during weight loss induced tissue remodelling using a planar protein array
11:00-11:10 WP 2.4: Prof. C. Thiele (P10) LD540, a new dye for lipid droplet imaging
11:10-11:20 WP 2.4: Dr. J. Weghuber (P24) Single molecule imaging on lipid droplets
11:20-11:30 WP 2.7: Dr. K. Böger (P02) Early intermediates in lipid droplet biogenesis
11:30-11:40 WP 2.4: Dr. M. Grandl (P01) High content imaging of lipid droplets and phospho-lipidosis in differentiated and lipid loaded human macrophages
11:40-11:50 WP 2.4: Z. Torok (P11): Single molecule imaging of membrane nanostructure and dynamics

WP 3, together with TF V

(Chair: Prof. C. Wolfrum P06)

Mouse models of liver and adipose lipid droplet processing
11:50-12:00 Prof. Dr. K. van Dijk (P05) KoWvD_HFDIO.ppt The role of high fat diets in adiposity, insulin sensitivity and hepatic inflammation 
12:00-12:15 Dr. E. Hajduch (P04). Caveolin-1 is critical for size enlargment of lipid droplets by regulating the organelle surface composition
12:15-12:30 Dr. H. Köfeler (P07) Lipid analysis of caveolin-null lipid droplets
12:30-12:40 Prof. Dr. C. Wolfrum (P06) Transcriptional control of adipogenesis

WP 4, together with TF VI + VII

(Chair: Prof. M. Wakelam P16)

Dysregulation of liver and adipose lipid droplet processing in human diseases
12:40-12:55 Prof. Dr. M. Wakelam (P13) MS analysis of LD content: Standards and preanalytics
12:55-13:05 Prof. Dr. Frederik Karpe (P22) Adipose tissue changes in response to insulin sensitization
13:05-14:05 Lunch
14:05-14:15 Dr. P. Ugocsai (P01) Sphingolipid and glycerophosholipid species and related polymorphic genes are associated with metablic overload risk
14:15-14:25 Dr. P. Ugocsai(P01) Sigruener_final_SC-Meeting_LipidomicNet.ppt ATP10D is a glucosylceramide translocase regulating lipid storage
14:25-14:40 PD Dr. M. Fischer Weight loss dependent modulation of adipose tissue and liver related biomarkers
14:40-14:50 Dr. V. Tarabin (P01) Transcriptional and metabolic changes during adipocyte differentiation
14:50-15:00 Prof. A. Dembinska-Kiec (P09) Changes in metabolism, lipid droplet accumulation and RE stress proteins in transdifferentiating human SVF cells
15:00-15:10 Dr. J. McLauchlan (P23) The impact of modulating lipid metabolism on lipid droplets and the HCV replication cycle

WP 5

(Chair: Prof. Schmitz P01)

Lipid droplets and lipid bodies in human macrophages and leukocytes
15:10-15:20 WP 5.2: P. Boström MD PhD

(P08 - UGOT)

Lipid Droplets in Human Macrophages Recruit Cytosolic Phospholipase A2 and Promote Secretion of Inflammatory Mediators
15:20-15:30 WP 5.1: Dr. J. Ecker (P01) SteeringC_120709.ppt The role of SREBP-1c mediated induction of lipid metabolism for macrophage differentiation
15:30-15:40 WP 5.1: Dr. M. Grandl (P01) Transcriptomic and Lipidomic analysis of lipid loaded human macrophages with an induction of lipid droplets or lamellar bodies in the endolysosomal compartment
15:40-15:50 WP 5.1: Dr. K. Leuthäuser-Jaschinski (P01) / Dr. E. Orsó (P01) Transcriptomic analysis of lipid-laden human Niemann-Pick disease type C macrophages
15:50 - 16:00 WP 5.4: K. Rübsaamen (P01) Lipidomic analysis of monocytes and granulocytes
16:00-16:10 WP 5.4: R. Guttzeit (P01) Influence of oral fat load on plasma and blood monocytes lipid species and transcriptomics
16:10-16:35 Coffee break

WP 6 (Chair: Dr. T. Kolter) Cellular lipid entry pathways into Lipid Droplets and Lamellar Bodies
16:35-16:50 WP 6.3: Dr. T. Kolter (P15) Analysis of cellular lipid uptake and processing
16:50-17:00 WP 6.4: Prof. J. Borlak (P01) to be completed by WP6 chair
17:00-17:15 WP 6.3: Dr. V. Olkkonen (P14) Lipid binding/transfer proteins with roles in cellular neutral lipid metabolism

WP 7, together with TF VIII

(Chair: Dr. L. Martens P16)

Bioinformatics
17:15-17:35 Dr. L. Martens (P16) overview of WP, recapitulation of work in first 6 months, LipidomicNet Wiki / Public availability of SPPs
17:35-17:45 Dr. F. Kolpakov (P19, ZORA) Lipidomics/metabolomics data processing
17:45-17:55 Dr. E. Gonzalez Couto

(P21, Integromics)

RT-PCR data processing
17:55-18:05 Dr. A. Kowald (P20, PROTAGEN) PRE_M12DelivReportTalk_001_090713_AKo.ppt Analysing protein chip data
18:05-18:15 J. Koopmann (P01) Microarray data processing
18:15-18:25 Dr. A. Kel (P18, BIOBASE) wp3 P18_BIOBASE_LipidomicNet_Regensburg_July_2009.ppt Mature adipocyte transcriptomics in mouse models of obesity

WP 8, together with TF IX

(Chair: Prof. A. Dembinska-Kiec P09)

Dissemination and training
18:25-18:35 Dr. I. Wybranska Progress in realisation of dissemination and training activity in the first year of the project
19:30 Meeting of WP-leaders/Management Team and SAC



Tuesday, 14.07.2009

Time Tuesday, 14.07.2009

Task Forces Reports
08:30-08:45 TF I: Mass-spectrometric and chromatogra-phic methods and preanalytics for molecular lipid species analyses and stable isotope labelling

(Chair: Dr. G. Liebisch / Dr. M. Köfeler)
Presentation, discussion and decision

to be completed by the TF-Chairman/Co-Chairman during the meeting
08:45-09:00 TF II: Fluorescence-based lipidomic methods on intact cells, labelling lipidomic antibodies and proteins

(Chair: Prof. C. Thiele)

Presentation, discussion and decision

to be completed by the TF-Chairman/Co-Chairman during the meeting
09:00-09:15

TF III: Affinity binder, ELISA and proteomic mass-spectrometric techniques and reagents

(Chair: Dr. S. Müllner)
Presentation, discussion and decision

to be completed by the TF-Chairman/Co-Chairman during the meeting
09:15-09:30 TF IV: ForceIV_Arrays_TLDA.ppt Gene-, Taqman- and Bead-array reagents and preanalytics (RNA/DNA, Agilent, Affymetrix, Illumina, ABI TLDAs

(Chair: Prof. G. Schmitz)
Presentation, discussion and decision

to be completed by the TF-Chairman/Co-Chairman during the meeting
09:30-09:45 TF V: Mouse models

(Chair: Prof. C. Wolfrum)
Presentation, discussion and decision

Animal models of aberrant lipid droplet formation - update


09:45-10:00 TF VI: Clinical trials and human ethics

(Chair: Dr. D. Gasperikova / Dr. J. Ukropec))
Presentation, discussion and decision

to be completed by the TF-Chairman/Co-Chairman during the meeting
10:00-10:15 TF VII: Human/Mouse translational research

(Chair: Prof. G. Schmitz)
Presentation, discussion and decision

to be completed by the TF-Chairman/Co-Chairman during the meeting
10:15-10:30 TF VIII: Bioinformatics

(Chair: Dr. L. Martens)
Presentation, discussion and decision

Bioinformatics - overcoming the challenges to bring it all together
10:30-10:45 TF IX: Dissemination, training and communication

(Chair Prof. A. Dembinska Kiec. L.)
Presentation, discussion and decision

to be completed by the TF-Chairman/Co-Chairman during the meeting
10:45-11:15 Coffee Break
11:15-12:00   Advisory-report of the Scientific Advisory Committee


Members of the SAC:
Prof. D. Brasaemle
Prof. E. Dennis
Prof. M. Wenk

12:00-13:00 Varia
13:00 End of meeting
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