Sphingolipids (SP)

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LIPID MAPS Subclasses


Sphingolipids (SP) are derivatives of long chain bases, as shown for ceramide and sphingosine-1-phosphate, and are composed of a hydrophobic moiety and a hydrophilic head group. They can be divided into two groups: the sphingophospholipids comprising of sphingomyelin, ceramide-1-phosphate, sphingosine-1-phosphate and sphingosylphosphorylcholine, and glycosphingolipids of the lacto-, globo- and ganglioside series.


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Biological processes associated

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There are several disorders of sphingolipid metabolism, known as sphingolipidoses. The most common is Gaucher's disease. Also of note is Fabry's disease, an X-linked recessive condition wherein a buildup of glycosphingolipids in lysosomes of various tissues is due to alpha-galactosidase deficiency. These patients tend to present with peripheral neuropathies and develop chronic renal conditions.


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