Bile acid regulation of lipid metabolism

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Bile acids not only regulate bile acid synthesis, but also regulate other pathways in the enterohepatic system including bile acid transport and absorption, RCT, lipoprotein metabolism, triglyceride metabolism, and drug metabolism. Ablation of the Fxr gene in mice increases serum bile acid, cholesterol and triglycerides, and results in a proatherogenic serum lipoprotein profile, consistent with the roles of FXR in bile acid synthesis, excretion and lipid metabolism (Sinal et al. 2000). Fig. 53 shows FXR, LXR, PXR and PPAR target genes involved in bile acid metabolism, RCT, triglyceride metabolism, lipoprotein metabolism and drug metabolism.

fig to be added 1 June 2011 noragon

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