ROR

From LipidomicsWiki

Retinoic acid receptor-related orphan receptors (ROR), a subfamily of orphan nuclear receptors, consist of three members termed alpha, beta and gamma. Through alternative splicing and promoter usage, each ROR gene generates several variants that are expressed in a tissue-specific manner and regulate specific target genes and physiological functions (Kang et al. 2007). RORa is ubiquitously expressed; the beta subtype is present in the brain, retina, pineal gland and spleen whereas RORg can be found at high levels in skeletal muscle and thymus (Giguere 1999). The three ROR proteins are closely related to each other both in their DNA-binding domain and Ligand-binding domain.