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Metabolism and subcellular compartmentalization of sphingolipids

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Sphingolipids are derivatives of long chain bases, as shown for ceramide and sphingosine-1- phosphate, and are composed of a hydrophobic moiety and a hydrophilic head group. They can be divided into two groups: the sphingophospholipids comprising of sphingomyelin, ceramide-1-phosphate, sphingosine-1-phosphate and sphingosylphosphorylcholine, and glycosphingolipids of the lacto-, globo- and ganglioside series. An overview of the sphingolipid metabolism is given in the figure below.

fig to be added 31 may 2011 noragon


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