Isoprostanes

From LipidomicsWiki

Basics

Isoprostanes (IsoPs) and COX-derived PGs have similar structures. The difference is that in IsoPs the side chains are predominantly in cis-formation in relation to the prostane ring whereas this orientation is trans in PGs. These molecules are synthesized from the free-radical induced peroxidation of AA. Hence, they are a potential biomarker of oxidative stress. In a contrast of other Isoprostanes (IsoPs), cyclopentenone Isoprostanes (IsoPs)(A2, J2) can readily conjugated with GSH. This can be one of the reasons while they can be detected just in a small content in humans. Cyclopentanone IsoPs are bioactive molecules. They have anti-inflammatory property: they can inhibit IKK, inhibit NF-kappaB DNA binding ability. They have also a positive effect on hsp70 and heme oxygenase-1 synthesis. As well as the above mentioned they are able to induce VEGF, too. (Ginger et al., 2005)

Technology

Analysis