From LipidomicsWiki
The biosynthesis of gangliosides (and glycosphingolipids in general) takes place on intracellular membranes (endoplasmic reticulum; Golgi apparatus) and is catalysed by membrane-bound enzymes. Transport of de novo produced compounds to the plasma membrane occurs via vesicles following the exocytotic membrane flow. Ganglioside (and glycosphingolipid, in general) degradation proceeds on the endocytotic route within the acidic compartments of the cell (late endosomes, lysosomes) by the action of hydrolytic enzymes (mostly soluble) assisted by activatory proteins and negatively charged lipids [Huwiler, 2000; Kolter 2002].Other pages in this category:
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