Eicosanoids (FA03)

From LipidomicsWiki

Contents 1 LIPID MAPS Subclasses 2 Basics 2.1 Structures 2.2 Natural sources 2.3 Nomenclature 2.4 Biophysical properties 3 Biochemical pathways 3.1 Biochemical synthesis 3.2 Metabolism 3.3 Degradation 4 Biological processes associated 5 Technology 5.1 Analysis methods 5.2 Chemical synthesis

LIPID MAPS Subclasses

• Prostaglandins (FA0301)
• Leukotrienes (FA0302)
• Thromboxanes (FA0303)
• Lipoxins (FA0304)
• Hydroxy/hydroperoxyeicosatrienoic acids (FA0305)
• Hydroxy/hydroperoxyeicosatetraenoic acids (FA0306) - HETEs
• Hydroxy/hydroperoxyeicosapentaenoic acids (FA0307)
• Epoxyeicosatrienoic acids (FA0308) - EETs
• Hepoxilins (FA0309)
• Levuglandins (FA0310)
• Isoprostanes (FA0311)
• Clavulones and derivatives (FA0312)
• Other Eicosanoids (FA0300)

Basics

Eicosanoids are metabolic products of three degradation pathways of arachidonic acid. The name comes from Greek word “eikosi”, which means “twenty” for the 20-carbon fatty acid of arachidonate. They constitute a class of oxygenated hydrophobic compounds that mostly act as paracrine mediators.

Structures

Natural sources

Nomenclature

• IUPAC
• LIPID MAPS Classification Scheme
• Trivial - non systematic - names

Biophysical properties

Biochemical pathways

Biochemical synthesis

Strg + Click to open Pathway in a new window / tab

Metabolism

Degradation

Biological processes associated

Link to Lipids as constituents of biological processes

Technology

Link to Lipidomics technologies

Analysis methods

• Eicosanoid determination - Harkewitz et al.
• Eicosanoid determination - Masoodi et al.
• Eicosanoid determination - Yue et al.

Chemical synthesis